Hanns-Ulrich Marschall Selected Research

Therapeutics

11/2023	Inhibition of the Renal Apical Sodium Dependent Bile Acid Transporter Prevents Cholemic Nephropathy in Mice with Obstructive Cholestasis.
1/2023	Clinical outcomes and sick leave in relation to UDCA treatment in Swedish patients with primary biliary cholangitis.
11/2022	Suppression of bile acid synthesis as a tipping point in the disease course of primary sclerosing cholangitis.
1/2022	Imbalanced gut microbiota fuels hepatocellular carcinoma development by shaping the hepatic inflammatory microenvironment.
7/2021	STE20-Type Protein Kinase MST4 Controls NAFLD Progression by Regulating Lipid Droplet Dynamics and Metabolic Stress in Hepatocytes.
1/2021	Silencing of STE20-type kinase MST3 in mice with antisense oligonucleotide treatment ameliorates diet-induced nonalcoholic fatty liver disease.
1/2021	Gut microbiota depletion exacerbates cholestatic liver injury via loss of FXR signalling.
1/2019	Targeted Delivery of Stk25 Antisense Oligonucleotides to Hepatocytes Protects Mice Against Nonalcoholic Fatty Liver Disease.
1/2018	Ursodeoxycholic acid: Effects on hepatic unfolded protein response, apoptosis and oxidative stress in morbidly obese patients.
1/2018	Serine/threonine protein kinase 25 antisense oligonucleotide treatment reverses glucose intolerance, insulin resistance, and nonalcoholic fatty liver disease in mice.

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Hanns-Ulrich Marschall Research Topics

Disease

24	Cholestasis 11/2023 - 12/2002
23	Liver Diseases (Liver Disease) 03/2024 - 12/2002
23	Fibrosis (Cirrhosis) 03/2024 - 02/2006
22	Intrahepatic Cholestasis of Pregnancy 11/2021 - 08/2004
21	Non-alcoholic Fatty Liver Disease 10/2023 - 09/2013
18	Sclerosing Cholangitis 01/2023 - 07/2004
17	Inflammation (Inflammations) 03/2024 - 02/2006
15	Pruritus (Itching) 01/2022 - 04/2003
11	Insulin Resistance 02/2024 - 01/2011
6	Biliary Liver Cirrhosis (Primary Biliary Cirrhosis) 01/2020 - 04/2015
5	Body Weight (Weight, Body) 03/2024 - 11/2005
5	Stillbirth 01/2021 - 03/2013
5	Dyslipidemias (Dyslipidemia) 01/2020 - 01/2011
4	Gestational Diabetes (Gestational Diabetes Mellitus) 02/2024 - 01/2019
4	Obesity 10/2023 - 08/2011
4	Liver Cirrhosis (Hepatic Cirrhosis) 01/2023 - 09/2013
4	Type 2 Diabetes Mellitus (MODY) 07/2022 - 09/2013
4	Fatty Liver 01/2022 - 01/2011
3	Glucose Intolerance 03/2024 - 01/2018
3	Disease Progression 01/2023 - 07/2010
3	Digestive System Diseases 01/2023 - 10/2013
3	Neoplasms (Cancer) 01/2022 - 06/2014
3	Gallstones (Gallstone) 11/2019 - 05/2010
3	Diarrhea 01/2018 - 12/2006
3	Weight Loss (Weight Reduction) 01/2016 - 09/2013
3	Infarction (Infarctions) 02/2006 - 10/2002
2	Hyperbilirubinemia 11/2023 - 01/2006
2	Hepatocellular Carcinoma (Hepatoma) 01/2023 - 02/2013
2	Intrahepatic Cholestasis 01/2022 - 01/2019
2	Autoimmune Hepatitis 01/2022 - 12/2017
2	Alcoholic Fatty Liver 01/2022 - 01/2018
2	Hyperglycemia 01/2022 - 01/2018
2	Premature Birth (Birth, Premature) 01/2021 - 01/2019
2	Cholangitis 01/2020 - 02/2006
2	Metabolic Diseases (Metabolic Disease) 01/2020 - 01/2017
2	Inflammatory Bowel Diseases (Inflammatory Bowel Disease) 01/2020 - 01/2020
2	Bile Duct Diseases (Bile Duct Disease) 01/2018 - 01/2017
2	Hyperinsulinism (Hyperinsulinemia) 01/2018 - 03/2008
2	Metabolic Syndrome (Dysmetabolic Syndrome X) 01/2016 - 08/2011
2	Cholelithiasis 07/2013 - 08/2004
1	Hyperlipidemias (Hyperlipidemia) 03/2024
1	Liver Neoplasms (Liver Cancer) 01/2023
1	Colitis 01/2023
1	Rickets (Rachitis) 08/2022
1	Avitaminosis (Vitamin Deficiency) 08/2022
1	Diabetes Mellitus 07/2022

Drug/Important Bio-Agent (IBA)

58	Bile Acids and Salts (Bile Acids)IBA 02/2024 - 12/2002
31	Ursodeoxycholic Acid (Urso)FDA LinkGeneric 01/2023 - 10/2002
17	LipidsIBA 07/2022 - 05/2010
11	Glucose (Dextrose)FDA LinkGeneric 03/2024 - 01/2011
11	Proteins (Proteins, Gene)FDA Link 10/2023 - 02/2006
8	obeticholic acidIBA 01/2020 - 09/2013
7	Messenger RNA (mRNA)IBA 10/2023 - 03/2016
6	Phosphotransferases (Kinase)IBA 10/2023 - 01/2021
6	Progesterone FDA LinkGeneric 01/2022 - 02/2008
6	Rifampin (Rifampicin)FDA LinkGeneric 11/2021 - 08/2005
6	CholesterolIBA 01/2021 - 05/2010
5	Protein Kinases (Protein Kinase)IBA 10/2023 - 01/2019
5	AcidsIBA 09/2021 - 06/2009
5	Protein Serine-Threonine Kinases (Protein-Serine-Threonine Kinase)IBA 01/2020 - 07/2017
4	Insulin (Novolin)FDA Link 02/2024 - 09/2013
4	Transaminases (Aminotransferases)IBA 01/2023 - 04/2003
4	Fibroblast Growth Factors (Fibroblast Growth Factor)IBA 11/2022 - 09/2013
4	Biomarkers (Surrogate Marker)IBA 01/2021 - 08/2005
4	Alanine Transaminase (SGPT)IBA 01/2019 - 09/2013
4	BilirubinIBA 08/2016 - 04/2003
3	Therapeutic UsesIBA 03/2024 - 06/2009
3	Fatty Acids (Saturated Fatty Acids)IBA 01/2023 - 03/2008
3	Cytoplasmic and Nuclear Receptors (Nuclear Receptors)IBA 10/2021 - 05/2006
3	Antisense OligonucleotidesIBA 01/2021 - 01/2018
3	LigandsIBA 01/2020 - 08/2005
3	Cholic AcidIBA 01/2020 - 08/2011
3	Alkaline PhosphataseIBA 08/2016 - 04/2015
3	EnzymesIBA 09/2013 - 08/2005
3	Cholestyramine Resin (Questran)FDA LinkGeneric 08/2011 - 04/2003
3	Dexamethasone (Maxidex)FDA LinkGeneric 02/2008 - 04/2003
2	RNA (Ribonucleic Acid)IBA 01/2023 - 03/2016
2	Sulfates (Sulfates, Inorganic)IBA 01/2022 - 04/2016
2	Tumor Necrosis Factor-alpha (Tumor Necrosis Factor)IBA 01/2020 - 03/2006
2	Triglycerides (Triacylglycerol)IBA 10/2019 - 08/2011
2	Glucagon-Like Peptide 1 (GLP 1)IBA 01/2019 - 01/2016
2	ORALIT (ORS)IBA 02/2017 - 10/2013
2	Glycine (Aminoacetic Acid)FDA LinkGeneric 01/2017 - 11/2013
2	Indicators and Reagents (Reagents)IBA 04/2016 - 11/2010
2	24-norursodeoxycholic acidIBA 06/2009 - 02/2006
2	Glutathione (Reduced Glutathione)IBA 08/2007 - 12/2002
1	Polysaccharides (Glycans)IBA 03/2024
1	beta-GlucansIBA 03/2024
1	(1-3)(1-4)- beta-glucanIBA 03/2024
1	sodium-bile acid cotransporterIBA 11/2023
1	LipopolysaccharidesIBA 01/2023
1	Phospholipids (Phosphatides)FDA LinkGeneric 01/2023
1	Phospholipases (Phospholipase)IBA 01/2023
1	teduglutideIBA 01/2023
1	oligofructoseIBA 01/2023

Therapy/Procedure

17	Therapeutics 11/2023 - 02/2006
7	Liver Transplantation 01/2022 - 07/2010
4	Ligation 11/2023 - 01/2017
2	Transplantation 01/2023 - 01/2020
2	Bariatric Surgery 01/2016 - 01/2011